|(1R,2R,3S,3aR,8bS)-1,8b-二羟基-6,8-二甲氧基-3a-(4-甲氧基苯基)-N,N-二甲基-3-苯基-2,3,3a,8b-四氢-1H-环戊二烯并[b]苯并呋喃-2-甲酰胺|CsnPharm

CAS No.: 84573-16-0

楝酰胺 Catalog No. CSN12999

Synonyms: 楝酰胺;Roc-A

Rocaglamide, a naturally occurring product isolated from the herbs of Aglaia odorata Lour, induces apoptosis through the intrinsic death pathway in various human leukemia cell lines and in acute lymphoblastic leukemia, chronic myeloid leukemia and acute myeloid leukemia cells freshly isolated from patients.

规格	价格	促销价格	库存	数量

400-920-2911

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技术信息

生物活性

描述Rocaglamide, a naturally occurring product isolated from the herbs of Aglaia odorata Lour, induces apoptosis through the intrinsic death pathway in various human leukemia cell lines and in acute lymphoblastic leukemia, chronic myeloid leukemia and acute myeloid leukemia cells freshly isolated from patients. It prevents tumor growth and sensitize resistant cancer cells to apoptosis by blocking the MEK-ERK-eIF4 pathway, and suppress the PMA-induced expression of NF-kappaB target genes and sensitize leukemic T cells to apoptosis induced by TNFalpha, cisplatin, and gamma-irradiation, suggests that rocaglamide derivatives could serve as lead structures in the development of anti-inflammatory and tumoricidal drugs.
参考文献

[1] Polier G, Neumann J, et al. The natural anticancer compounds rocaglamides inhibit the Raf-MEK-ERK pathway by targeting prohibitin 1 and 2. Chem Biol. 2012;19(9):1093-104
[2] Baumann B, Bohnenstengel F, et al. Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T-cells. J Biol Chem. 2002;277(47):44791-800

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.9780 mL
- 9.8900 mL
- 19.7801 mL
- 5 mM
- 0.3956 mL
- 1.9780 mL
- 3.9560 mL
- 10 mM
- 0.1978 mL
- 0.9890 mL
- 1.9780 mL

技术信息

CAS号

84573-16-0

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C29H31NO7

运输

蓝冰

分子量

505.56

别名

楝酰胺;Roc-A

溶解度

DMSO	98.0 mg/mL (193.8 mM)
Water	Insoluble
Ethanol	10.0 mg/mL (19.8 mM)

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